SUPERFAMILY 1.75 HMM library and genome assignments server


WW domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   WW domain-like [ 51044] (3)
Superfamily:   WW domain [ 51045]
Families:   WW domain [ 51046] (12)


Superfamily statistics
Genomes (445) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 14,293 12,227 31
Proteins 9,202 7,810 29


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular macromolecule metabolic process 3.884e-13 Least Informative Direct
Biological Process (BP) protein metabolic process 9.952e-08 Least Informative Direct
Biological Process (BP) developmental process 1.757e-06 Least Informative Direct
Biological Process (BP) multicellular organismal process 3.15e-05 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.000102 Least Informative Direct
Biological Process (BP) response to stimulus 0.0002958 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.02071 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.7976 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) localization 0.007997 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.6906 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of programmed cell death 1.98e-07 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 3.01e-06 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 1.491e-05 Moderately Informative Direct
Biological Process (BP) regulation of localization 2.267e-05 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 4.048e-05 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 7.459e-05 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.0003674 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.0005892 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.3896 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.8012 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.3463 Moderately Informative Inherited
Biological Process (BP) tissue development 0.2544 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) system process 0.05985 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.649 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.1376 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.974 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.8383 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.1679 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.1422 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.003194 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.0563 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.09968 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.1018 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.2623 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.03701 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.03865 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.002477 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.7063 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.5013 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.1379 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.162 Moderately Informative Inherited
Biological Process (BP) gene expression 0.1973 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.07395 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.1132 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.1626 Moderately Informative Inherited
Biological Process (BP) protein catabolic process 1.048e-13 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 1.883e-10 Informative Direct
Biological Process (BP) positive regulation of transport 4.03e-08 Informative Direct
Biological Process (BP) proteolysis 6.145e-08 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 3.632e-07 Informative Direct
Biological Process (BP) regulation of cell cycle 3.042e-06 Informative Direct
Biological Process (BP) negative regulation of cell communication 1.765e-05 Informative Direct
Biological Process (BP) locomotion 1.907e-05 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 2.916e-05 Informative Direct
Biological Process (BP) negative regulation of signaling 3.672e-05 Informative Direct
Biological Process (BP) cytoplasmic transport 0.0002502 Informative Direct
Biological Process (BP) blood circulation 0.0004318 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.0004343 Informative Direct
Biological Process (BP) cell projection organization 0.0006017 Informative Direct
Biological Process (BP) protein complex assembly 0.0007319 Informative Direct
Biological Process (BP) protein transport 0.0009397 Informative Direct
Biological Process (BP) regulation of apoptotic signaling pathway 0.4944 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.3949 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.01858 Informative Inherited
Biological Process (BP) regulation of locomotion 0.06544 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.03801 Informative Inherited
Biological Process (BP) generation of neurons 0.07557 Informative Inherited
Biological Process (BP) cellular component movement 0.0199 Informative Inherited
Biological Process (BP) protein localization to organelle 0.9318 Informative Inherited
Biological Process (BP) membrane organization 0.04451 Informative Inherited
Biological Process (BP) epithelium development 0.03483 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.07143 Informative Inherited
Biological Process (BP) muscle structure development 0.001991 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 0.6849 Informative Inherited
Biological Process (BP) regulation of cell development 0.05172 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.1071 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.5226 Informative Inherited
Biological Process (BP) regulation of growth 0.05669 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.9678 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.5277 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.00122 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 0.8177 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.08276 Informative Inherited
Biological Process (BP) regulation of nucleotide catabolic process 0.04246 Informative Inherited
Biological Process (BP) regulation of purine nucleotide metabolic process 0.04562 Informative Inherited
Biological Process (BP) regulation of nucleoside metabolic process 0.2733 Informative Inherited
Biological Process (BP) negative regulation of developmental process 1 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.9741 Informative Inherited
Biological Process (BP) chromosome organization 0.003158 Informative Inherited
Biological Process (BP) organ morphogenesis 0.2346 Informative Inherited
Biological Process (BP) RNA processing 0.07532 Informative Inherited
Biological Process (BP) single-organism behavior 0.883 Informative Inherited
Biological Process (BP) cell cycle process 0.001923 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.8249 Informative Inherited
Biological Process (BP) embryonic organ development 0.3169 Informative Inherited
Biological Process (BP) cardiovascular system development 0.5389 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.8019 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.8294 Informative Inherited
Biological Process (BP) regulation of ion transport 0.01249 Informative Inherited
Biological Process (BP) localization of cell 0.003784 Informative Inherited
Biological Process (BP) protein ubiquitination 0 Highly Informative Direct
Biological Process (BP) ubiquitin-dependent protein catabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of transmembrane transport 5.78e-10 Highly Informative Direct
Biological Process (BP) regulation of transporter activity 6.419e-10 Highly Informative Direct
Biological Process (BP) regulation of sodium ion transport 3.971e-08 Highly Informative Direct
Biological Process (BP) negative regulation of cell cycle 4.367e-08 Highly Informative Direct
Biological Process (BP) regulation of protein catabolic process 5.855e-08 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 1.964e-06 Highly Informative Direct
Biological Process (BP) regulation of protein kinase B signaling cascade 2.603e-06 Highly Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 4.075e-06 Highly Informative Direct
Biological Process (BP) RNA splicing 4.164e-06 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 1.145e-05 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 4.636e-05 Highly Informative Direct
Biological Process (BP) negative regulation of sequence-specific DNA binding transcription factor activity 6.657e-05 Highly Informative Direct
Biological Process (BP) mRNA processing 9.561e-05 Highly Informative Direct
Biological Process (BP) renal system development 0.0001178 Highly Informative Direct
Biological Process (BP) cell part morphogenesis 0.000131 Highly Informative Direct
Biological Process (BP) chemotaxis 0.0003004 Highly Informative Direct
Biological Process (BP) peptidyl-lysine modification 0.0003381 Highly Informative Direct
Biological Process (BP) regulation of Rho protein signal transduction 0.0003711 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.0009676 Highly Informative Direct
Biological Process (BP) neuron projection development 0.01827 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell differentiation 0.003057 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.001911 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.001083 Highly Informative Inherited
Biological Process (BP) regulation of protein stability 0.003133 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.002445 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.1733 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.1817 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.2171 Highly Informative Inherited
Biological Process (BP) regulation of blood pressure 0.002214 Highly Informative Inherited
Biological Process (BP) stem cell development 0.2218 Highly Informative Inherited
Biological Process (BP) positive regulation of GTPase activity 0.1844 Highly Informative Inherited
Biological Process (BP) regulation of Ras GTPase activity 0.01656 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.9829 Highly Informative Inherited
Biological Process (BP) epidermal cell differentiation 0.4877 Highly Informative Inherited
Biological Process (BP) protein methylation 0.002163 Highly Informative Inherited
Biological Process (BP) histone modification 0.01134 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.7232 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.8908 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 0.004099 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.02402 Highly Informative Inherited
Molecular Function (MF) binding 1.167e-13 Least Informative Direct
Molecular Function (MF) structural molecule activity 4.375e-07 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0.3844 Moderately Informative Inherited
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 4.13e-06 Informative Direct
Molecular Function (MF) enzyme binding 5.12e-05 Informative Direct
Molecular Function (MF) amide binding 0.0002889 Informative Direct
Molecular Function (MF) receptor binding 0.005103 Informative Inherited
Molecular Function (MF) enzyme activator activity 0.001096 Informative Inherited
Molecular Function (MF) GTPase regulator activity 0.008834 Informative Inherited
Molecular Function (MF) small conjugating protein ligase activity 0 Highly Informative Direct
Molecular Function (MF) channel regulator activity 7.874e-12 Highly Informative Direct
Molecular Function (MF) peptide binding 9.405e-07 Highly Informative Direct
Molecular Function (MF) transcription factor binding transcription factor activity 8.282e-06 Highly Informative Direct
Molecular Function (MF) GTPase activator activity 0.0001131 Highly Informative Direct
Molecular Function (MF) protein complex binding 0.0009015 Highly Informative Direct
Molecular Function (MF) small GTPase regulator activity 0.07547 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) membrane 0.3937 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.08819 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.1014 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) cell projection 1.539e-09 Moderately Informative Direct
Cellular Component (CC) ribonucleoprotein complex 3.63e-06 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.0001109 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.01268 Moderately Informative Inherited
Cellular Component (CC) plasma membrane part 0.8948 Moderately Informative Inherited
Cellular Component (CC) synapse part 2.58e-06 Informative Direct
Cellular Component (CC) cell leading edge 1.491e-05 Informative Direct
Cellular Component (CC) ubiquitin ligase complex 0.0007863 Informative Direct
Cellular Component (CC) cell-cell junction 0.9396 Informative Inherited
Cellular Component (CC) actin cytoskeleton 0.7002 Informative Inherited
Cellular Component (CC) spliceosomal complex 1.14e-14 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 1.159e-07 Highly Informative Direct
Cellular Component (CC) actin filament 5.883e-05 Highly Informative Direct
Cellular Component (CC) adherens junction 0.000311 Highly Informative Direct
Cellular Component (CC) small nuclear ribonucleoprotein complex 0.0004329 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring one-carbon groups1.4e-12Least InformativeDirect
Enzyme Commission (EC)Isomerases4.689e-05Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.003595Least InformativeInherited
Enzyme Commission (EC)Methyltransferases5.085e-15Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an7.733e-06Moderately InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0InformativeDirect
Enzyme Commission (EC)Peptidylprolyl isomerase9.564e-14InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.2002Least InformativeInherited
Disease Ontology (DO)neuromuscular disease0.007617InformativeInherited

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.03939Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.1036Least InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.03453Moderately InformativeInherited
Mammalian Phenotype (MP)muscle phenotype0.1045Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.2135Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.4872Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryogenesis/ development1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lung morphology0.08659InformativeInherited
Mammalian Phenotype (MP)increased apoptosis0.338InformativeInherited
Mammalian Phenotype (MP)abnormal rostral-caudal body axis extension1.996e-05Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.004131Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.08902Least InformativeInherited
Worm Phenotype (WP)chemical response variant0.003814Moderately InformativeInherited
Worm Phenotype (WP)drug resistant0.1295InformativeInherited
Worm Phenotype (WP)aldicarb resistant0.0007778Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)protein/peptide modification0.0005214Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.6928Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1.818e-13Moderately InformativeDirect
Enzyme Commission (EC)Isomerases6.165e-05Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.003832Moderately InformativeInherited
Enzyme Commission (EC)Histone-lysine N-methyltransferase0InformativeDirect
Enzyme Commission (EC)RNA helicase2.446e-08InformativeDirect
Enzyme Commission (EC)Peptidylprolyl isomerase9.498e-14Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0Moderately InformativeDirect
Biological processApoptosis9.866e-14Moderately InformativeDirect
Biological processUbl conjugation pathway0InformativeDirect
Biological processNeurogenesis8.746e-10InformativeDirect
Biological processWnt signaling pathway8.505e-08InformativeDirect
Biological processmRNA splicing0.0002148InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentMembrane0.02414Least InformativeInherited
Cellular componentCytoplasm0.02452Least InformativeInherited
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCytoskeleton2.493e-10Moderately InformativeDirect
Cellular componentCell membrane3.769e-08Moderately InformativeDirect
Cellular componentCell projection0.0006832Moderately InformativeDirect
Cellular componentChromosome9.561e-14InformativeDirect
Cellular componentSpliceosome3.322e-06InformativeDirect
Cellular componentTight junction2.102e-05Highly InformativeDirect
Coding sequence diversityAlternative splicing1.093e-07Least InformativeDirect
DiseaseProto-oncogene0.000132Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainSH3 domain7.205e-05InformativeDirect
Molecular functionCalcium0.0002776Moderately InformativeDirect
Molecular functionActin-binding1.721e-10InformativeDirect
Molecular functionS-adenosyl-L-methionine0.0001514InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationRepressor1.409e-14Moderately InformativeDirect
Post-translational modificationActivator4.273e-08Moderately InformativeDirect
Post-translational modificationLigase6.046e-08Moderately InformativeDirect
Post-translational modificationIsomerase0.18Moderately InformativeInherited
Post-translational modificationChromatin regulator1.039e-08InformativeDirect
Post-translational modificationGTPase activation1.358e-08InformativeDirect
Post-translational modificationMethyltransferase4.556e-05InformativeDirect
Post-translational modificationRotamase8.537e-09Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation2.678e-07Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR001202 SSF51045 Protein matches
Abstract

Synonym(s): Rsp5 or WWP domain

The WW domain is a short conserved region in a number of unrelated proteins, which folds as a stable, triple stranded beta-sheet. This short domain of approximately 40 amino acids, may be repeated up to four times in some proteins [PubMed7846762, PubMed7802651, PubMed7828727, PubMed7641887]. The name WW or WWP derives from the presence of two signature tryptophan residues that are spaced 20-23 amino acids apart and are present in most WW domains known to date, as well as that of a conserved Pro. The WW domain binds to proteins with particular proline-motifs, [AP]-P-P-[AP]-Y, and/or phosphoserine- phosphothreonine-containing motifs [PubMed7644498, PubMed11911877]. It is frequently associated with other domains typical for proteins in signal transduction processes.

A large variety of proteins containing the WW domain are known. These include; dystrophin, a multidomain cytoskeletal protein; utrophin, a dystrophin-like protein of unknown function; vertebrate YAP protein, substrate of an unknown serine kinase; Mus musculus (Mouse) NEDD-4, involved in the embryonic development and differentiation of the central nervous system; Saccharomyces cerevisiae (Baker's yeast) RSP5, similar to NEDD-4 in its molecular organization; Rattus norvegicus (Rat) FE65, a transcription-factor activator expressed preferentially in liver; Nicotiana tabacum (Common tobacco) DB10 protein and others.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 17 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a WW domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 17 hidden Markov models representing the WW domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]