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WW domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   WW domain-like [ 51044] (3)
Superfamily:   WW domain [ 51045]
Families:   WW domain [ 51046] (12)


Superfamily statistics
Genomes (503) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 16,034 40,078 31
Proteins 10,352 25,683 29


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) macromolecule metabolic process 0.000000009922 Least Informative Direct
Biological Process (BP) biological regulation 0.00000000001762 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.000005952 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.6572 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.001611 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.08639 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.8178 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.7384 Least Informative Inherited
Biological Process (BP) response to stimulus 0.3501 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.6676 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.6225 Least Informative Inherited
Biological Process (BP) cellular protein modification process 0.00001438 Moderately Informative Direct
Biological Process (BP) cell communication 0.0008777 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0.00000006436 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0.0000002653 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.00009607 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.00001534 Moderately Informative Direct
Biological Process (BP) single organism signaling 0.0003314 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.00000832 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0.0003119 Moderately Informative Direct
Biological Process (BP) cellular developmental process 0.000007265 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.0003794 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.00009646 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0.0001051 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0.2423 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.6241 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.8203 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.002227 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.2856 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.1552 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 0.001748 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.6839 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.3098 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.4795 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 0.02805 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.02802 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.2852 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.00525 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.00208 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.03181 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.9258 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.1375 Moderately Informative Inherited
Biological Process (BP) gene expression 0.04143 Moderately Informative Inherited
Biological Process (BP) system development 0.02984 Moderately Informative Inherited
Biological Process (BP) proteolysis 0.0005639 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.00000716 Informative Direct
Biological Process (BP) cell cycle process 0.00002822 Informative Direct
Biological Process (BP) negative regulation of signaling 0.000001853 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.0004158 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0.00000009116 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.0000675 Informative Direct
Biological Process (BP) positive regulation of transport 0.000027 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.0001155 Informative Direct
Biological Process (BP) regulation of hydrolase activity 0.00008568 Informative Direct
Biological Process (BP) regulation of cell cycle 0.0000008073 Informative Direct
Biological Process (BP) single-organism intracellular transport 0.0006157 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.05519 Informative Inherited
Biological Process (BP) regulation of ion transport 0.2708 Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.05591 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.06127 Informative Inherited
Biological Process (BP) protein oligomerization 0.09153 Informative Inherited
Biological Process (BP) behavior 0.03223 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.1563 Informative Inherited
Biological Process (BP) regulation of growth 0.008432 Informative Inherited
Biological Process (BP) regulation of phosphorylation 1 Informative Inherited
Biological Process (BP) intracellular protein transport 0.1259 Informative Inherited
Biological Process (BP) negative regulation of transport 0.1234 Informative Inherited
Biological Process (BP) regulation of catabolic process 0.006403 Informative Inherited
Biological Process (BP) regulation of locomotion 0.04586 Informative Inherited
Biological Process (BP) tissue development 0.006081 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.4905 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.02693 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.03997 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 0.04137 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.6661 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.002666 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.9204 Informative Inherited
Biological Process (BP) chromosome organization 0.04248 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.2686 Informative Inherited
Biological Process (BP) system process 0.3312 Informative Inherited
Biological Process (BP) post-embryonic development 0.9123 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.0293 Informative Inherited
Biological Process (BP) protein localization to organelle 0.7737 Informative Inherited
Biological Process (BP) cell development 0.002624 Informative Inherited
Biological Process (BP) kidney development 0.0000003652 Highly Informative Direct
Biological Process (BP) mRNA processing 0.00000005649 Highly Informative Direct
Biological Process (BP) RNA splicing 0.000002909 Highly Informative Direct
Biological Process (BP) peptidyl-lysine modification 0.000502 Highly Informative Direct
Biological Process (BP) regulation of protein stability 0.0001727 Highly Informative Direct
Biological Process (BP) protein modification by small protein conjugation 0 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 0.000019 Highly Informative Direct
Biological Process (BP) modification-dependent macromolecule catabolic process 0 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 0.00002212 Highly Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.0000004301 Highly Informative Direct
Biological Process (BP) proteolysis involved in cellular protein catabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0.000004573 Highly Informative Direct
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.0000005645 Highly Informative Direct
Biological Process (BP) plasma membrane bounded cell projection organization 0.00001836 Highly Informative Direct
Biological Process (BP) regulation of cation transmembrane transport 0.0000002298 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.001747 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 0.008225 Highly Informative Inherited
Biological Process (BP) negative regulation of mitotic cell cycle 0.1786 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular signal transduction 0.002734 Highly Informative Inherited
Biological Process (BP) neurological system process 0.9203 Highly Informative Inherited
Biological Process (BP) single-organism behavior 0.1022 Highly Informative Inherited
Biological Process (BP) anatomical structure homeostasis 0.002761 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.1569 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.1556 Highly Informative Inherited
Biological Process (BP) protein localization to membrane 0.005409 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.06176 Highly Informative Inherited
Biological Process (BP) protein alkylation 0.0149 Highly Informative Inherited
Biological Process (BP) histone modification 0.002252 Highly Informative Inherited
Biological Process (BP) macromolecule methylation 0.01987 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 1 Highly Informative Inherited
Biological Process (BP) post-embryonic animal morphogenesis 0.06503 Highly Informative Inherited
Biological Process (BP) muscle structure development 0.001759 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.4051 Highly Informative Inherited
Biological Process (BP) appendage development 0.2606 Highly Informative Inherited
Molecular Function (MF) binding 0.000000002391 Least Informative Direct
Molecular Function (MF) transferase activity 0.002339 Least Informative Inherited
Molecular Function (MF) structural molecule activity 0.000000004992 Moderately Informative Direct
Molecular Function (MF) molecular function regulator 0.0006677 Moderately Informative Direct
Molecular Function (MF) receptor binding 0.0009152 Informative Direct
Molecular Function (MF) enzyme binding 0.00002849 Informative Direct
Molecular Function (MF) amide binding 0.01026 Informative Inherited
Molecular Function (MF) macromolecular complex binding 0.001819 Informative Inherited
Molecular Function (MF) transcription factor activity, transcription factor binding 0.00003002 Highly Informative Direct
Molecular Function (MF) G-protein coupled receptor binding 0.0000000276 Highly Informative Direct
Molecular Function (MF) ubiquitin-like protein transferase activity 0 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.0000001172 Highly Informative Direct
Molecular Function (MF) peptide binding 0.0003315 Highly Informative Direct
Cellular Component (CC) membrane 0.4612 Least Informative Inherited
Cellular Component (CC) macromolecular complex 0.005255 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.4682 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.3555 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0.0006492 Moderately Informative Direct
Cellular Component (CC) cell projection 0.00008132 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.0003699 Moderately Informative Direct
Cellular Component (CC) membrane protein complex 0.0005011 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.3355 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.01037 Moderately Informative Inherited
Cellular Component (CC) synapse 0 Informative Direct
Cellular Component (CC) plasma membrane protein complex 0.0000000007415 Informative Direct
Cellular Component (CC) nucleoplasm part 0.03564 Informative Inherited
Cellular Component (CC) spliceosomal complex 0.00001412 Highly Informative Direct
Cellular Component (CC) nuclear body 0.000001327 Highly Informative Direct
Cellular Component (CC) small nuclear ribonucleoprotein complex 0.0007659 Highly Informative Direct
Cellular Component (CC) sarcolemma 0.000007292 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.000003551 Highly Informative Direct
Cellular Component (CC) cell-cell junction 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring one-carbon groups0.0000000000014Least InformativeDirect
Enzyme Commission (EC)Isomerases0.00004689Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.003595Least InformativeInherited
Enzyme Commission (EC)Methyltransferases0.000000000000005085Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0.000007733Moderately InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0InformativeDirect
Enzyme Commission (EC)Peptidylprolyl isomerase0.00000000000009564InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.05379Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.136Least InformativeInherited
Mammalian Phenotype (MP)abnormal muscle physiology0.01666Moderately InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.2092Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.3233Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.438Moderately InformativeInherited
Mammalian Phenotype (MP)embryo phenotype0.621Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.664Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle morphology0.8727Moderately InformativeInherited
Mammalian Phenotype (MP)increased apoptosis0.2601InformativeInherited
Mammalian Phenotype (MP)abnormal embryo development0.3563InformativeInherited
Mammalian Phenotype (MP)abnormal rostral-caudal body axis extension0.0001634Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart electrocardiography waveform feature0.01567Highly InformativeInherited
Mammalian Phenotype (MP)bundle branch block1Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.0715Least InformativeInherited
Worm Phenotype (WP)chemical response variant0.04492Moderately InformativeInherited
Worm Phenotype (WP)maintenance of gene silencing variant0.0003122InformativeDirect
Worm Phenotype (WP)aldicarb response variant0.002674InformativeInherited
Worm Phenotype (WP)drug resistant0.125InformativeInherited
Worm Phenotype (WP)aldicarb resistant0.0009919Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups0.01146Moderately InformativeInherited
Enzyme Commission (EC)Isomerases0.02306Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides0.1546Moderately InformativeInherited
Enzyme Commission (EC)Histone-lysine N-methyltransferase0InformativeDirect
Enzyme Commission (EC)RNA helicase0.000006112InformativeDirect
Enzyme Commission (EC)HECT-type E3 ubiquitin transferase0Highly InformativeDirect
Enzyme Commission (EC)Peptidylprolyl isomerase0.0000000002644Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0Moderately InformativeDirect
Biological processUbl conjugation pathway0Moderately InformativeDirect
Biological processApoptosis0.000000000000235Moderately InformativeDirect
Biological processDifferentiation0.000002298Moderately InformativeDirect
Biological processmRNA processing0.00000000000002913InformativeDirect
Biological processNeurogenesis0.000000003434InformativeDirect
Biological processWnt signaling pathway0.0000001156InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm0.02323Least InformativeInherited
Cellular componentMembrane0.02595Least InformativeInherited
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCytoskeleton0.00000000006681Moderately InformativeDirect
Cellular componentCell membrane0.00000002008Moderately InformativeDirect
Cellular componentCell projection0.00001089Moderately InformativeDirect
Cellular componentChromosome0.000000000000543InformativeDirect
Cellular componentSpliceosome0.000006976InformativeDirect
Cellular componentTight junction0.00003949Highly InformativeDirect
Coding sequence diversityAlternative splicing0.0000003807Least InformativeDirect
DiseaseProto-oncogene0.0002301Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainSH3 domain0.00008361InformativeDirect
Molecular functionCalcium0.0005969Moderately InformativeDirect
Molecular functionS-adenosyl-L-methionine0.0004071InformativeDirect
Post-translational modificationTransferase0.008947Least InformativeInherited
Post-translational modificationRepressor0Moderately InformativeDirect
Post-translational modificationActivator0.0000000004657Moderately InformativeDirect
Post-translational modificationIsomerase0.2033Moderately InformativeInherited
Post-translational modificationActin-binding0.0000000002857InformativeDirect
Post-translational modificationChromatin regulator0.000000001557InformativeDirect
Post-translational modificationGTPase activation0.00000002446InformativeDirect
Post-translational modificationMethyltransferase0.0009525InformativeDirect
Post-translational modificationRotamase0.00000001065Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation0.00000000000003378Moderately InformativeDirect
Post-translational modificationIsopeptide bond0.000001815Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR001202 SSF51045 Protein matches
Abstract

Synonym(s): Rsp5 or WWP domain

The WW domain is a short conserved region in a number of unrelated proteins, which folds as a stable, triple stranded beta-sheet. This short domain of approximately 40 amino acids, may be repeated up to four times in some proteins [PubMed7846762, PubMed7802651, PubMed7828727, PubMed7641887]. The name WW or WWP derives from the presence of two signature tryptophan residues that are spaced 20-23 amino acids apart and are present in most WW domains known to date, as well as that of a conserved Pro. The WW domain binds to proteins with particular proline-motifs, [AP]-P-P-[AP]-Y, and/or phosphoserine- phosphothreonine-containing motifs [PubMed7644498, PubMed11911877]. It is frequently associated with other domains typical for proteins in signal transduction processes.

A large variety of proteins containing the WW domain are known. These include; dystrophin, a multidomain cytoskeletal protein; utrophin, a dystrophin-like protein of unknown function; vertebrate YAP protein, substrate of an unknown serine kinase; Mus musculus (Mouse) NEDD-4, involved in the embryonic development and differentiation of the central nervous system; Saccharomyces cerevisiae (Baker's yeast) RSP5, similar to NEDD-4 in its molecular organization; Rattus norvegicus (Rat) FE65, a transcription-factor activator expressed preferentially in liver; Nicotiana tabacum (Common tobacco) DB10 protein and others.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 17 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a WW domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 17 hidden Markov models representing the WW domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]