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Actin-crosslinking proteins superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   beta-Trefoil [ 50352] (8)
Superfamily:   Actin-crosslinking proteins [ 50405] (2)
Families:   Fascin [ 50406]
  Histidine-rich actin-binding protein (hisactophilin) [ 50409]

Superfamily statistics
Genomes (504) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 2,692 6,539 5
Proteins 1,772 4,638 2

Functional annotation
General category Processes_IC
Detailed category Cell motility

Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Molecular Function (MF)binding00.002454Least InformativeInherited
Molecular Function (MF)cytoskeletal protein binding00InformativeDirect
Molecular Function (MF)macromolecular complex binding00InformativeDirect
Molecular Function (MF)actin filament binding00.00000000009379Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0.0004027 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.002918 Least Informative Inherited
Biological Process (BP) organelle organization 0.0000001327 Moderately Informative Direct
Biological Process (BP) cellular component assembly 0.05653 Moderately Informative Inherited
Biological Process (BP) cytoskeleton organization 0.0000000000002877 Informative Direct
Biological Process (BP) actin filament-based process 0.00000000000003638 Informative Direct
Biological Process (BP) locomotion 0.0003548 Informative Direct
Biological Process (BP) supramolecular fiber organization 0.0000001737 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.003878 Informative Inherited
Biological Process (BP) actin filament organization 0.06304 Highly Informative Inherited
Molecular Function (MF) binding 0.002454 Least Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0 Informative Direct
Molecular Function (MF) macromolecular complex binding 0 Informative Direct
Molecular Function (MF) actin filament binding 0.00000000009379 Highly Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.0000005807 Least Informative Direct
Cellular Component (CC) cytoskeleton 0.0001784 Moderately Informative Direct
Cellular Component (CC) cell projection 0.005602 Moderately Informative Inherited
Cellular Component (CC) actin cytoskeleton 0 Informative Direct
Cellular Component (CC) neuron projection 0.00007689 Informative Direct

Document: GO annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)brain0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)visual system0Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processRibosome biogenesis0.00000003031InformativeDirect
Biological processrRNA processing0.0000002219InformativeDirect
Biological processMyogenesis0Highly InformativeDirect
Cellular componentCytoplasm0.00003933Least InformativeDirect
Cellular componentCytoskeleton0.000000000005001Moderately InformativeDirect
Cellular componentCell projection0.00000000508Moderately InformativeDirect
Post-translational modificationActin-binding0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008999 SSF50405 Protein matches

This entry represents an actin-crosslinking domain with a beta-trefoil structure, consisting of a triplet of beta-hairpins packed against a six-stranded antiparallel beta-barrel. Proteins containing this domain include fascin, which carries a tandem repeat of four copies of this domain, and the histidine-rich actin-binding protein hisactophilin. Actin-crosslinking proteins organise actin filaments into dynamic and complex subcellular scaffolds that orchestrate important mechanical functions, including cell motility and adhesion [PubMed15992772].

The fascins are a structurally unique and evolutionarily conserved group of actin cross-linking proteins. Fascins function in the organisation of two major forms of actin-based structures: dynamic, cortical cell protrusions and cytoplasmic microfilament bundles [PubMed12507891].

A related protein, hisactophilin, is an essential protein for the osmoprotection of dictyostelium cells [PubMed11847289, PubMed11996675].

InterPro database

PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a Actin-crosslinking proteins domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the Actin-crosslinking proteins superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]