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Actin-crosslinking proteins superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   beta-Trefoil [ 50352] (8)
Superfamily:   Actin-crosslinking proteins [ 50405] (2)
Families:   Fascin [ 50406]
  Histidine-rich actin-binding protein (hisactophilin) [ 50409]

Superfamily statistics
Genomes (506) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 2,723 6,539 5
Proteins 1,785 4,638 2

Functional annotation
General category Processes_IC
Detailed category Cell motility

Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Molecular Function (MF)binding00.003145Least InformativeInherited
Molecular Function (MF)macromolecular complex binding00InformativeDirect
Molecular Function (MF)cytoskeletal protein binding00InformativeDirect
Molecular Function (MF)actin filament binding00.00000000009911Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0.0004071 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.002685 Least Informative Inherited
Biological Process (BP) organelle organization 0.0000001177 Moderately Informative Direct
Biological Process (BP) cellular component assembly 0.05643 Moderately Informative Inherited
Biological Process (BP) actin cytoskeleton organization 0 Informative Direct
Biological Process (BP) supramolecular fiber organization 0.0000001995 Informative Direct
Biological Process (BP) localization of cell 0.00001363 Informative Direct
Biological Process (BP) locomotion 0.0003983 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.004608 Informative Inherited
Biological Process (BP) actin filament organization 0.05584 Highly Informative Inherited
Molecular Function (MF) binding 0.003145 Least Informative Inherited
Molecular Function (MF) macromolecular complex binding 0 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0 Informative Direct
Molecular Function (MF) actin filament binding 0.00000000009911 Highly Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.0000006056 Least Informative Direct
Cellular Component (CC) cytoskeleton 0.0002143 Moderately Informative Direct
Cellular Component (CC) cell projection 0.006186 Moderately Informative Inherited
Cellular Component (CC) actin cytoskeleton 0 Informative Direct
Cellular Component (CC) neuron projection 0.00008867 Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processRibosome biogenesis0.00000003067InformativeDirect
Biological processrRNA processing0.0000002178InformativeDirect
Biological processMyogenesis0Highly InformativeDirect
Cellular componentCytoplasm0.00003753Least InformativeDirect
Cellular componentCytoskeleton0.000000000005268Moderately InformativeDirect
Cellular componentCell projection0.000000005396Moderately InformativeDirect
Post-translational modificationActin-binding0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008999 SSF50405 Protein matches

This entry represents an actin-crosslinking domain with a beta-trefoil structure, consisting of a triplet of beta-hairpins packed against a six-stranded antiparallel beta-barrel. Proteins containing this domain include fascin, which carries a tandem repeat of four copies of this domain, and the histidine-rich actin-binding protein hisactophilin. Actin-crosslinking proteins organise actin filaments into dynamic and complex subcellular scaffolds that orchestrate important mechanical functions, including cell motility and adhesion [PubMed15992772].

The fascins are a structurally unique and evolutionarily conserved group of actin cross-linking proteins. Fascins function in the organisation of two major forms of actin-based structures: dynamic, cortical cell protrusions and cytoplasmic microfilament bundles [PubMed12507891].

A related protein, hisactophilin, is an essential protein for the osmoprotection of dictyostelium cells [PubMed11847289, PubMed11996675].

InterPro database

PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a Actin-crosslinking proteins domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the Actin-crosslinking proteins superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]